Conti 3 , Lida Chatzi 3 and Lucy Golden-Mason 1 , (1)USC Research Center for Liver Diseases, Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, (2)Department of Population and Public Health Sciences, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, (3)Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California Background: Exposure to steatogenic environmental pollutants increases the risk of non-alcoholic fatty liver disease (NAFLD) development and progression to non-alcoholic steatohepatitis (NASH)
Examples of these specific detoxification systems are the glyoxalase system, which removes the reactive aldehyde methylglyoxal, [4] and the various antioxidant systems that eliminate reactive oxygen species
You see, without adequate glutathione to keep free radical levels in check, these harmful molecules begin causing unprecedented levels of oxidative damage
3582-C Nrf2 ACTIVATOR OMAVELOXOLONE PROTECTS MICE FROM ALCOHOL INDUCED LIVER INJURY Claire Montgomery, Gino Cortopassi and Joy Jiang, UC Davis Background: Alcohol-induced oxidative stress is a hallmark and major pathogenic factor of alcohol-associated liver disease (ALD)