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Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

Singleton et al

Top right : Defective RyR1 channels remain open, resulting in excessive Ca release from the SR into the cytoplasm and loss of intracellular calcium homeostasis

Since oxidation participates as an essential messenger of cellular signaling pathways, treatment of oxidative stress needs to consider maintaining that physiologic threshold (230, 231)