glutathione argyria (Argyrosis, Argyriasis, Amalgam tattoo) Systemic argyria associated with ingestion

This results in damage to the DNA strands and activation of the DDR [72]

The most frequent symptoms are: Developmental delays Anaemia Loss of appetite Chronic vomiting Weight loss Low brain volume Spasms/cramps Apathy Irritability In the most severe instance, vitamin B12 deficiency can lead to respiratory failures and coma (51)

Eur Neurol 37(4):225 Mashayekhi F, Salehi Z (2016) Administration of vitamin D 3 induces CNPase and myelin oligodendrocyte glycoprotein expression in the cerebral cortex of the murine model of cuprizone-induced demyelination

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