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In erastin- or RSL3-induced ferroptosis in hepatocellular carcinoma cells, IFN- triggers the JAK-STAT-IRF1 axis and inhibits transcription of the System Xc subunits SLC3A2 and SLC7A11 ( 4.2.2 Other key signaling pathways NF-KB signaling lies at the nexus of many inflammatory cytokines and immune receptors, thus exerting bidirectional effects on ferroptosis

This can be genetically determined, but it can also be caused by inflammation of the intestinal mucosa (e.g

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10.3390/ijms21051711 188 HopfnerF.KnstnerA.MllerS