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Patients should administer three injections together at the start of the cluster period and may repeat this dose monthly until the cluster period ends

The release of inflammatory factors, such as cytokines and chemokines, by activated microglia can contribute to the perpetuation of neuroinflammation and exacerbate neuronal apoptosis (programmed cell death)

Data availability The datasets used and analyzed during the current study are available from the corresponding author on reasonable request and with permission of the Research Ethics Committee of the School of Medicine-Shiraz University of Medical Sciences

Ann Rev Physiol