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Step 2: Preparation The injection area is cleaned, and we review treatment expectations

These channels promote intercellular communication by permitting the release of gliotransmitters such as adenosine triphosphate (ATP) and glutamate, as well as calcium ions (Ca 2+ ), which are essential in neuroinflammatory mechanisms [11]

(ISBN: 978-0-07-149618-6) Keywords Cocaine Toxicology Source: Drug of abuse Mechanism of Action: CNS stimulant blocks the reuptake of catecholamines: dopamine, norepinephrine & serotonin (DAT, NET & SERT transporters) Na and K channel blocker (at slightly higher doses than those blocking reuptake of catecholamines commonly coadministered with ethanol to create cocaethylene which has a longer half-life (and prolonged high) Symptoms: CNS : Euphoria , which may be followed by anxiety & agitation Psychatric symptoms (including paranoia, psychosis & the sensation of something crawling on the skin or itchy skin) Hyperactivity & Seizures (usually self limiting

Apart from exogenous sources, ROS and RNS are also produced endogenously via partial reduction of molecular oxygen (O 2 ) in the respiratory chain within the mitochondria [18]