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While it is known that skin cells can produce estrogens locally, aromatase enzyme activity is dramatically reduced to approximately 30 times lower than in premenopausal ovarian follicular tissue [10]

Ferroptosis mediates airway epithelial E-cadherin dysfunction in LPS-induced acute lung injury

It regulates blood glucose levels by enhancing insulin secretion in pancreatic cells and reducing glucagon release (180)

ACKNOWLEDGMENTS This work was supported by the Spanish Ministry of Science and Innovation PI2016/01, CB06/05/0024 (CIBERNED), the European Regional Development Founds and MAT 2014-59134-R project