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While the roles of neurotransmitters are dynamic, and can switch depending on age and circumstance, the fact that neurotransmitter classes are well-elucidated, and we are learning more and more about their contributions to health and disease, creates optimism that we can uncover the molecular mechanism(s) of neurostimulation

Recent studies have highlighted the utility of biomarkers, such as NGF and BDNF, in predicting the progression of neuropathy and response to therapy

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1,2 Each of these definitions carries a different meaning, and what the half-life of a drug is found to be can also vary or appear to vary depending on contexts such as formulation, route of administration, and individual variations in drug distribution, metabolism, and excretion, among other factors