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By increasing melanin levels in the skin, MT-I creates a natural shield that absorbs UV light before it reaches protoporphyrin IX [13]

Given that 2D and 3D cell culture cannot fully reproduce physiological conditions, in vivo studies provide added value for clinical studies

A possible reason could be that these three enzymes are related to maintenance of adequate reduced glutathione levels, whereas GPx1 is involved in its direct consumption

4.2 Vitamin D: a vital nutrient in health and autoimmunity While nutritional components like ginger regulate gut health and immunity through the natural consumption of foods, nutritional supplements like vitamin D are major regulators of immune activity and balance of gut microbiota