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Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis

More importantly, there are several aspects of irAEs that we do not understand and which are the source of several controversies in the field

Indeed, recent work has likewise implicated cell cycle arrest, induced either by p53 activation or CDK4/6 inhibition, in sensitizing fibrosarcoma cells to GPX4 inhibition 51