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In aging, dark spots on the skin may be caused by free radicals that cause eumelanin formation.[ref] Glutathione has been shown in a number of studies to lighten age spots, and it is thought that both its antioxidant effect and a shift towards pheomelanin formation are at the root of these antiaging skin properties.[ref] Lets switch gears here and look at how your genetic variants impact your need for glutathione: Genotype report: Access this content: An active subscription is required to access this content