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A., Sherr, D

These oxysterols activate the LXR signaling pathway in B lymphocytes, triggering an LXR-dependent transcriptional network that potentiates cholesterol efflux ( Cholesterol sulfate, synthesized by sulfotransferase 2B1 (SULT2B1) in tumor cells, is secreted to suppress dedicator of cytokinesis protein 2 (DOCK2) enzymatic activity in T cells, leading to CD8 + T cell exhaustion ( + Ly6G + neutrophils, along with an increase in F4/80-CD11b + CD11c + dendritic cells and T cells, which play key roles in the immune response

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In some patients, they may also signal nutritional deficiency, worsening of an underlying condition, or the need for medical intervention