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A compound of formula VI: (VI) wherein: R 2 is selected from the group consisting of: hydrogen, +PO(OY) 2 , +PO(OH) 2 , and - C(=0)-Y, where Y is -Z-(CH2)q-W-R b , q is 0-4, where Z and W are independently selected from the group consisting of: CH2, O, S, R C and R b , where R c is selected from the group consisting of: hydrogen, C1-C4 alkyl, and C3-C6 cycloalkyl, R b is selected from the group consisting of: hydrogen, C1-C12 alkyl, C1-C12 substituted alkyl, C3-C8 cycloalkyl, C3-C8 substituted cycloalkyl, C3-C8 heterocycloalkyl, and C3-C8 substituted heterocycloalkyl

By contrast, the share of applicants reporting musculoskeletal impairments, which are commonly associated with chronic pain, was unchanged during this period

GLP-1 receptor agonists and gallbladder disease risk

Always consult with a qualified healthcare provider regarding any medical concerns