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Capsaicin increases the generation of lipid peroxidation products in vitro but not in vivo , and this response is blocked by receptor antagonist capsazepine (Leonelli et al., 2010)

However, its half-life in the bloodstream is remarkably short, around 15 minutes, due to rapid degradation by aminopeptidase enzymes

doi: 10.3390/nu14010231 61 SalarolliRTAlvarengaLCardozoLTeixeiraKTRdeSGMLLimaJDet al

These conditions may also coincide with nutritional deficiencies, particularly of cysteine and glycine, which are required for glutathione synthesis, further impairing the cycle and promoting diversion toward PGA production [70, 71]