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S2) demonstrated the minimal tumor volume, lowest tumor weight, and maximum survival time, confirming the superior therapeutic efficacy of the combined administration of DOX, Zn 2+ and Nrf2 siRNA (Fig

Weidner C, de Groot JC, Prasad A, Freiwald A, Quedenau C, Kliem M, Witzke A, Kodelja V, Han CT, Giegold S, Baumann M, Klebl B, Siems K, Mller-Kuhrt L, Schrmann A, Schler R, Pfeiffer AF, Schroeder FC, Bssow K, Sauer S

This pathway is initiated by a combination of Patched and Hh proteins, consisting of Sonic Hh (Shh), Desert Hh, and Indian Hh (Ihh), which allows Smoothened to transmit signals to the nucleus