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Recombinant strains exhibited a differential response during SSF with 10% solids As there were no discernible differences in the physiology of the recombinant strains during SSF using 5% solids, the WIS content was increased to 10% under the hypothesis that a higher concentration of inhibitors present in the raw material would enable us to delineate the phenotypic differences between the strains without killing the cells rapidly

M., McDowell, S

Furthermore, downregulation of GPX4 via genetic deletion or chemical inhibition can lead to ferroptosis in T cells, while upregulation of GPX4 and genetic deletion of ACSL4 can suppress ferroptosis in CD8+ T cells (88, 89)

A dose-related decrease in the expression of all the hypothalamic neuropeptides studied was found in response to AFB1, leading to alteration inducing appetite disorders as a macroscopic effect (87)