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In a subsequent study using NFE2L2/PGC1 double knockout (dKO) mice model, they observed upregulation of autophagy markers PINK1 and PARKIN together with damaged mitochondria, with no increase in the colocalization of lysosomal marker (LAMP2) and mitochondrial marker (ATP synthase ), suggesting an inability of the autophagosome to fuse with the lysosome (Sridevi Gurubaran et al., 2020)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Jakaria M., Cho D.Y., Haque M.E., Karthivashan G., Kim I.S., Ganesan P., Choi D.K