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H., Wei, H., Huang, M., Chang, D

doi: 10.3389/fendo.2023.1294406 45 KamalDAMSalamtNYusufANMKashimMIAMMokhtarMH

Indirect calorimetry Mice were housed singly in Sable Systems metabolic cages at room temperature (24 C)

There is a practical ceiling to how much peptide the sublingual tissue can absorb in a single administration, and for poorly-absorbed compounds, that ceiling falls below therapeutic thresholds