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The close proximity of the B 12 and BV cofactors in the photocobilins allows interaction and cross-talk between them, meaning excitation of BV triggers B 12 photochemistry

In male mouse models of amyloidosis, such as APP/PS1 and TASD41 (hAPP751 with the London V717I9/Swedish double mutation K670M/N671L), aggressive behavior correlates with a progressive increase in amyloid plaque size and density in cortical, hippocampal, and amygdala regions (Morgastrern et al., 2018)