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J Hazard Mater 446:130702

The value of this variable, called Z B , can be calculated for each titration point according to Equation (1): (1) In Equation (1), H is the total concentration of protons in the solution (calculated according to Equation (2) below), h is the free concentration of protons in the solution (calculated according to Equation (3) below), [OH ] is the concentration of hydroxide ions in solution and B is the total concentration of DHBA in the solution (calculated according to Equation (4) below)

Thus, Pb 2+ -induced neurotoxicity is multifactorial and occurs through several distinct mechanisms, including lead-induced oxidative stress, divalent cation mimicry, mitochondrial dysfunction, increased neuroinflammation, and enhanced brain permeability