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Description

JP-8exposed animals also demonstrated a nonsignificant decrease in performance on the rotarod test when compared to unexposed controls, whereas no rotarod performance differences were observed following exposure to petroleum- or shale-derived JP-5

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This pathway is considered the most genotoxic as the 4-OH estrogen metabolites can become reactive quinones that have the potential to bind to DNA and form damaging (unstable) depurating adducts, that may increase risk for cancer, such as breast and prostate cancer