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This was different to the pattern in the brain in which Bmal1 was more highly expressed compared to Clock

Even just a little bit is really bad

It is important to note that the effect of ROS in circulating or infiltrating immune cells depends on the site of production, especially in case of autoimmunity where ROS induce Treg activation while limiting T cell proliferation and cytokine production [108,109,110,111], resulting in dampened disease activity