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Inhibitors of EAAT activity are grouped into competitive (bind to the same binding sites as glutamate) and non-competitive (bind somewhere else, i.e., to an allosteric site)

[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Crawford R.R., Prescott E.T., Sylvester C.F., Higdon A.N., Shan J., Kilberg M.S., Mungrue I.N

Taken together, these findings suggest that P-gp may exacerbate infection-associated harm, with its deficiency conferring protective benefits to the host

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