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Lipid metabolism reprogramming in chronic obstructive pulmonary disease

Finally, evidence highlighting the importance of calorie reduction originates from the observation that LCD (as discussed in chapter Low-Carbohydrate Diet [LCD]) are only successful in reducing IHLC when integrated into a hypocaloric diet approach, but fail to decrease or even increase IHLC if carbohydrate restriction occurs at the expense of increased fat intake in an isocaloric manner [36,37]

It is a carnitine specific transporter that disappeared during evolution: it is present in mouse, but not in chimpanzee or humans (Pochini et al., 2013)

Its proposed mechanisms include the enhancement of lipid metabolism, improvement of insulin sensitivity, stabilization of hepatocyte function, and reduction of inflammation, fibrosis, and tumorigenesis