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Subsequent clinical cases revealed that -synuclein pathology is not only restricted to the soma but also extends to neurites which led to the coinage of the term Lewy neurites ( Under normal physiological conditions -synuclein exists mostly in an N acetylated membrane bound form which results in adoption of an -helical structure (Runfola et al., 2020)

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The fluorescence emission (FL emission) spectra were obtained with a Hitachi F7000 fluorescence spectrophotometer (Tokyo, Japan)

DJ-1 regulates astrogliosis through stabilization of Sox9 [119], a transcription factor that regulates gliogenesis during development of the brain [123,124], and astogliosis in injured brain [125,126]