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5 Hypoxic stress at high altitude can trigger a series of physiological responses across multiple organ systems, especially the brain (increased cerebral blood flow), pulmonary system (increased ventilation and pulmonary vascular remodeling), cardiovascular system (increased heart rate, cardiac output, and systemic blood pressure), renal system (increased bicarbonate excretion and erythropoietin (EPO) secretion), and hematologic system (increased red cell mass, hemoglobin (Hb) concentration, and hematocrit (Hct)), thereby increasing oxygen content and delivery in the body

Because passive wrapping is ineffective for some amphiphilic drugs, active loading methods have been developed to reduce leakage while improving efficiency [33]

While they show potential in enhancing therapeutic outcomes in cancer and other oxidative stress-related pathologies, challenges still remain like variable efficacy, lack of the standardization of doses, toxicity linked with high doses, etc

(2021) Food and microbiota metabolites associate with cognitive decline in older subjects: a 12-year prospective study