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Indeed, only fully reduced pterins such as tetrahydrobiopterin have ever been shown to support catalysis [3436]

Its defining pharmacological feature is negligible cortisol and prolactin co-stimulation at GH-stimulating doses, making it the preferred compound in research protocols where isolated GH-axis stimulation is required

Peters RS, Krogmann L, Mayer C, Donath A, Gunkel S, Meusemann K, Kozlov A, Podsiadlowski L, Petersen M, Lanfear R, Diez PA, Heraty J, Kjer KM, Klopfstein S, Meier R, Polidori C, Schmitt T, Liu S, Zhou X, Wappler T, Rust J, Misof B, Niehuis O (2017) Evolutionary history of the Hymenoptera