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Ethics statement All experimental protocols were approved by the Scientific Ethics Committee of Huazhong Agricultural University (HZAUSW-2023-0062), and animal experiments were conducted in accordance with the recommendations of the Guide for the Care and Use of Laboratory Animals Monitoring Committee of Hubei Province, China

Niacin: chemical forms, bioavailability, and health effects

Relapse during the double-blind phase was defined as having 2 or more binge days each week for two consecutive weeks (14 days) prior to any visit and having an increase in CGI-S score of 2 or more points compared to the randomized-withdrawal baseline