glutathione s transferase chalcone Chalcone: A Privileged Structure in Medicinal Chemistry Role of Chalcones in Gastrointestinal

N.MishraB

Mitochondrial calcium homeostasis holds significant importance in maintaining the functionality of neurons and glial cells (58)

its inhibition in Alzheimers models triggers inflammation and oxidative cascades

Abbreviations ARE: Antioxidant response element ASN: Asparagine CCK-8: Cell counting kit-8 CETSA: Cellular thermal shift assay CHX: Cycloheximide CNS: Central nervous system DA: Dopamine DAergic: Dopaminergic DOPAC: 3,4-Dihydroxy phenylacetic acid ELISA: Enzyme-linked immunosorbent assay EPS: Epalrestat FBS: Fetal bovine serum GCLC: Glutamate-cysteine ligase catalytic subunit GSH: Glutathione HO-1: Heme oxygenase-1 HPLC-ECD: High-performance liquid chromatography with electrochemical detection HVA: Homovanillic acid KEAP1: Kelch-like ECH-associating protein 1 LCMS/MS: Liquid chromatography-tandem mass spectrometry LDH: Lactate dehydrogenase MAO-B: Monoamine oxidase B MDA: Malondialdehyde m: Mitochondrial membrane potential MPP + : 1-Methyl-4-phenylpyridillium ion MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine N2a: Neuro-2a mouse neuroblastoma NQO1: NAD(P)H: quinone oxidoreductase-1 Nrf2: Nuclear factor erythroid 2-related factor OFT: Open field test PD: Parkinsons disease ROS: Reactive oxygen species SER: Serine siRNA: Small interfering RNA SN: Substantia nigra SPR: Surface plasmon resonance TEM: Transmission electron microscopy References Berg D, Postuma RB, Bloem B, Chan P, Dubois B, Gasser T, Goetz CG, Halliday GM, Hardy J, Lang AE, et al