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Chemical resolution Currently, the synthesis of R -ALA on an industrial scale depends on the direct chemical resolution of its racemic mixture, ALA, using R -(+)-methylbenzylamine (RAMBA) as the chiral resolution reagent (Scheme 16)

The gained information has allowed to explain some phenomena observed in toxicological studies performed at the level of cell cultures and of isolated tissue and organ preparations, and to finally propose an explanation for the peculiar toxicological behavior ( i.e

Although, the exact cause of these diseases is not identified, emerging research has highlighted that oxidative stress plays a critical role in their pathogenesis [3, 25]

Am J Psychiat 148: 14741486