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Rusu AV, Trif M, Rocha JM (2023) Microbial secondary metabolites via fermentation approaches for dietary supplementation formulations

An in vitro AlphaScreen technology binding assay showed that IACS-16898 is a potent inhibitor of CREB-binding protein (CBP), the paralog of p300, with an IC 50 of 3 nM versus a reported IC 50 of 4790 nM for BRD4 (Fig

Potential Benefits: Fertility Preservation: Maintains intratesticular testosterone and spermatogenesis during TRT [3] [4]

First, most studies included small sample sizes predominantly composed of healthy young female participants, which limits statistical power and reduces the generalizability of results to clinical populations