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Static compression significantly inhibits the viability, migration, clonogenicity, and multidifferentiation potential of NP-MSCs and reduces their stemness, suggesting it may play an important role in hindering endogenous disc repair ( Furthermore, the physical properties of the substrate (such as stiffness and fiber alignment) also significantly regulate stem cell differentiation

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98 Melatonin is thought to reduce tinnitus by protecting hair cells (sensory cells in the ear responsible for hearing) from oxidative damage, promoting normal blood flow to inner ear structures, relaxing ear muscles, attenuating depression and anxiety, inhibiting the stress response, and supporting normal sleep patterns