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Owing to the pronounced heterogeneity of IBD, biologics and small-molecule agents elicit highly variable responses, with approximately 3040% of patients experiencing primary or secondary loss of response [17]

Extracellular vesicles as a next-generation drug delivery platform

Int J Mol Sci 21:6351 Sparano JA, Lee JY, Kaplan LD, Levine AM, Ramos JC, Ambinder RF, Wachsman W, Aboulafia D, Noy A, Henry DH (2010) Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma