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The study used a single high dose and did not evaluate symptoms, disease outcomes or long-term use

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Besides, high ROS levels in senescent cells also require more NADPH to maintain redox balance

Status and utilization of medicinal and aromatic plants in eastern Hararghe, Ethiopia

GC production and secretion are tightly regulated by feedback mechanisms, primarily mediated by cortisol binding to glucocorticoid receptors (GR) and mineralocorticoid receptors (MR), which initiate negative feedback inhibition at multiple levels of the central nervous system and the HPA axis (Watzka et al., 2000)