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In physiological settings wherein the GSH/GSSG redox couple is highly reduced, mammalian GLRX1 (hereafter referred to as GLRX) acts predominantly as a deglutathionylase 5

2.4.2 Isolation of blood peripheral mononuclear cells and cell culture Blood was collected at 12-, 14-, and 16-weeks post-inoculation

doi: 10.1016/j.ecoenv.2020.110956 35 WangJZhuMWangLChenCSongY

For comparison, and as a control to assess the specificity of BDNF among other known neuronal activity-regulated paracrine factors 1,2,3 , soluble NLGN3 was similarly tested and exerted no acute effect on glutamatergic current amplitude in glioma cells (Extended Data Fig