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Zileuton, an FDA-approved oral medication for treating asthma, is an ALOX5 inhibitor that exerts neuroprotective effects by blocking ALOX5-mediated glutamate toxicity and ferroptosis in HT22 cells, a mouse hippocampal cell line [301]

We further explored the regulation of NEDD4 expression and found that PRMT1 knockdown inhibited the expression of NEDD4 (Fig

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Additionally, intracellular reactive oxygen species (ROS) accumulation and endoplasmic reticulum (ER) stress exacerbate MOMP