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5AC), indicating that iron overload does not affect ovarian function through hormone level regulation

Beyond AMPK activation, metformin exerts pleiotropic effects, including the modulation of gut microbiota and suppression of hepatic gluconeogenesis, as detailed in Table 1

Nevertheless, if such formulations can demonstrably enhance exposure two- to three-fold, reduce dosing frequency, or minimize adverse effects relative to standard therapy, they may ultimately prove cost-effective by lowering reliance on multiple drugs and reducing downstream healthcare costs