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More hydrophilic conjugates would be expected to display a decreased binding to plasma proteins, but published investigations suggested that a change in plasma protein binding was dependent on the polyphenol and its type and position of conjugation ( TABLE 3 Degree of phase II conjugation of compounds detected in serum/plasma after intake of Pycnogenol and plasma protein binding of Pycnogenol constituents and metabolites

Wang A, Chen X, Wang L, Jia W, Wan X, Jiao J, Yao W, Zhang Y (2022) Catechins protect against acrylamide- and glycidamide-induced cellular toxicity via rescuing cellular apoptosis and DNA damage