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Lakkadwala S, Dos Santos Rodrigues B, Sun C, Singh J

(2015), it was shown that excessive mitochondrial fission induced by Drp1 activation leads to increased production of mitochondrial ROS, which activates the NLRP3 inflammasome, promoting inflammation (Park et al., 2015)

[137] found that the sesquiterpene CA-4 in the seed extract of Artemisia argyi exerts anti-inflammatory effects through a dual mechanism: 1) Inhibiting the MAPK pathway (phosphorylation of ERK/JNK), down-regulating the expression of iNOS/COX-2, and blocking the polarization of M1 macrophages

Abstract Despite promise of its supplementation as both monotherapy and add-on treatment in autism spectrum disorder (ASD), the biobehavioral effects of Palmitoylethanolamide (PEA) in autistic adults have never been explored so far