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Based on what we see at our Doral clinic, the patients who benefit most look like this: A soft-tissue injury that stalled: physical therapy is complete, there is no surgical indication, but the patient is still symptomatic at 8 to 12 weeks

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PE-22-28: TREK-1 Channel Blockade# PE-22-28 (Gly-Val-Ser-Trp-Gly-Leu-Arg) is a synthetic 7-amino acid peptide derived from spadin, itself an endogenous peptide released by proteolytic processing of sortilin (neurotensin receptor-3)

Consistency is more important than timing