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In this cycle, GSH is released from the cell by carrier mediated transporter(s) and the ecto-enzyme GGT then transfers the -glutamyl moiety of GSH to an amino acid (the best acceptor being cystine), forming -glutamyl amino acid and cysteinylglycine

Additionally, it was reported that trimetazidine (TMZ), a piperazine derivative, mediated activation of the GSH system and had antioxidant and cytoprotective effects in several myocardial injury models [210,211,212,213]

Its a concurrent feature of obesity and related conditions like diabetes

A study conducted in the UK similarly found that mortality rates in COVID-19 patients were twice as high in Bangladeshi communities and 1050% higher in other ethnic minority communities when compared to the white British population (28)