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Over the last few years, these guidelines have been updated to address findings from recent clinical trials and ongoing experience with these drugs

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Kynurenine metabolism: the link between kynurenine metabolism and astrocytes The kynurenine pathway (KP), responsible for the breakdown of tryptophan into kynurenine and its subsequent conversion into quinolinic acid, picolinic acid, acetyl-CoA, and NAD, plays a critical role in the production of cellular energy through NAD formation