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YDYXJJ2025-0024), the Yunnan University Graduate Research Innovation Fund (No

Abbreviations CALCOCO2: Calcium binding and coiled-coil domain-containing protein 2 DPP: Diabetes Prevention Program ECM: Extracellular matrix ER: Endoplasmic reticulum GLP-1: Glucagon-like peptide-1 GWAS: Genome-wide association studies HNF1A: Hepatocyte nuclear factor 1- IGT: Impaired glucose tolerance ITFG3: Integrin FG-GAP repeat containing 3 PE: Pancreatic elastase SIDD: Severe insulin-deficient diabetes TMAO: Trimethylamine N -oxide UPR: Unfolded protein response References Esser N, Utzschneider KM, Kahn SE (2020) Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia

Li J-h, Chen Y, Ye Z-h, Chen L-p, Xu J-x, Han J et al (2024) Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DSS-induced colitis

Safety, efficacy, and biomarker findings of PBT2 in Alzheimers disease: a randomized, double-blind, placebo-controlled phase IIa study