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Additionally, it also suppressed apoptotic pathways by downregulating the expression of Egr-1 and Caspase-3 mRNA

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

In response to SASP, macrophages are recruited into the articular space and secrete proinflammatory factors to activate synovial fibroblasts, which promote osteophyte formation and further exacerbating osteoarthritis [140]