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Diphenylene iodonium (DPI), a NOX inhibitor, was found to prevent erastin-induced ferroptosis in KRAS mutant Calu-1 non-small cell lung cancer cells ( Thioredoxin, a member of cellular antioxidant family (Nordberg and Arner, 2001), plays an important role in suppressing ferroptosis by maintaining and regulating the redox homeostasis

Cells were then treated with lipopolysaccharide at a final concentration of 1 g/mL for 24 h to induce an inflammatory response

Supports metabolism & weight management

Oxidant-antioxidant balance disorders are the most important mechanisms known in the pathogenesis of this disease (141)