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Lu, Y.-Y., Ma, X.-J

Furthermore, diverse mechanisms of inhibition, including selective, dual-targeted, allosteric, covalent, PROTACs, and PPI-targeted approaches, are enhancing drug-like properties, safety, and efficacy

In preclinical research, AOD9604 is primarily investigated for its selective lipolytic activitythe ability to stimulate fat breakdown (lipolysis) and inhibit fat synthesis (lipogenesis) without exhibiting the growth-promoting or diabetogenic effects of full-length growth hormone

In contrast to many other peptide hormones, IGFs are avidly bound to specific IGFBPs, which significantly increases the half-life of IGF-1 in circulation.The seven classes of IGFBPs which are known at present 1,3,4 either bind IGF-1 and IGF-2 with similar affinities or show a preference for IGF-2