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doi: 10.3389/fnsys.2021.698240 [DOI] [PMC free article] [PubMed] [Google Scholar] 436

Signaling and Synthesis: The prolonged, unbound presence of IGF-1 LR3 in the bloodstream maximizes the anabolic signaling effect on muscle tissue, activating intracellular signaling pathways that promote protein synthesis and muscle fiber hypertrophy (increase in cell size)