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Black Box Warnings (abbreviated version): Because of the possibility of serious toxic (and potentially fatal) reactions, methotrexate should be used only in life threatening neoplastic diseases or severe recalcitrant psoriasis or rheumatoid arthritis which is not responsive to other forms of therapy

Acute excitotoxicity is known to play an important role in specific CNS disorders including cerebral ischemia, TBI, and status epilepticus

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