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CoQ10 has potent antioxidant effects on the mitochondrial membrane, as well as other membranes in the cell and in the plasma and cytoplasm

Given that microglia can exhibit both pro-inflammatory and anti-inflammatory phenotypes depending on the context, future research is likely to explore ways to fine-tune microglial responses to promote neuroprotection and reduce neuroinflammation

The HMGB1/5HT7R/Nrf2/xCT/GPX4 pathway was found to promote ferroptosis of M2 microglia in transient middle cerebral artery occlusion (tMCAO) mice, which promoted ischemic brain injury and depressive-like behaviors

doi: 10.1016/j.molcel.2019.02.038 46 HuJTianM