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Furthermore, increased strand breaks generation caused activation of poly(ADP-ribose) polymerase (PARP), a zinc finger DNA-binding protein, known to deplete intracellular NAD + reserves as well as energy stores, thus ultimately resulting in cell death (429)

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More detailed reporting of trial participation at the trial level in a publicly accessible database would allow for a more informative analysis of key trends in NIH-funded clinical trials, further contributing to transparency and accountability